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| 12:00–13:45 | Registration |
| 13:45–13:50 | Opening |
| 13:50–14:00 | Welcome (Anastassis Perrakis; NKI) |
| Chair: Jiri Novacek | |
| 14:00–14:30 | Christiane Berger-Schaffitzel: Discovery of a druggable pocket and a drug in SARS-CoV-2 spike glycoprotein |
| 14:30–15:00 | Mikael Akke: Resolving Protein–Ligand Binding Pathways by NMR relaxation: Conformational Selection vs Induced Fit |
| 15:00–15:30 | Richard Stefl: Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5 helicase |
| 15:30–16:00 | Coffee break |
| Chair: Manfred Weiss | |
| 16:00–16:30 | Elspeth Garman: Radiation damage and metal identification in Structural Biology: why do we care? |
| 16:30–17:00 | Petra Wendler: Visualizing electrons in redox proteins by single particle cryo-EM |
| 17:00–17:45 | Poster flash talks |
| 18:00–21:00 | Poster session and BBQ dinner in the hotel |
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| Chair: Jiri Novacek | |
| 8:30–9:00 | Gergely Papp: EasyGrid: a versatile platform for automated Cryo-EM sample preparation and control |
| 9:00–9:30 | Carlos Oscar Sorzano: Advances in the stream processing of single particles by CryoEM |
| 9:30–10:00 | Enrico Luchinat: Detecting protein-drug interactions in human cells by real-time 19F NMR |
| 10:00–10:30 | Bernhard Brutscher: Light-NMR: what can we learn about photo-transformable fluorescent proteins? |
| 10:30–11:00 | Coffee break |
| Chair: Eva Pereiro (Partners' JRA) | |
| 11:00–11:30 | Evgenia Zagoriy: Streamlining cryo-corellative multi-scale imaging of multicellular samples |
| 11:30–12:00 | Joaquin Oton: Advancing Correlative Microscopy: Automated Alignment of cryo-3D-SIM and Soft X-ray Tomography Data – Strategies and Implementation |
| 12:00–12:30 | Genevieve Evans: Building a Fragment Screening Data Pilot Repository: Challenges and Opportunities |
| 12:30–13:00 | Sponsor's contribution – Bruker: Magnet Innovations, Liquid State NMR Probes and Software News from Bruker BioSpin |
| 13:00–13:10 | Group photoshoot |
| 13:10–14:00 | Buffet lunch |
| Chair: Rebecca Thompson | |
| 14:00–14:30 | Andras Perczel: Chemical evolution of the aggregation-prone regions by means of amyloid formation |
| 14:30–15:00 | Daniel Rozbesky: Molecular mechanisms of MICAL signaling in cytoskeletal dynamics |
| 15:00–15:30 | Gustavo Fuertes: A divide-and-conquer structural biology approach to elucidate the photocycle of light-regulated transcription factor EL222 |
| 15:30–16:00 | Coffee break |
| Chair: Hans Wienk | |
| 16:00–16:30 | Kevin Gardner: Using structural biology to transform nature’s switches into our biotech tools and therapeutics |
| 16:30–17:00 | Elda Bauda: Ultrastructural details of the bacterial spore revealed by in situ cryo-electron tomography |
| 17:00–18:00 | Round Table: Panel members on iNEXT-Discovery |
| 18:30–20:30 | Spilberk Castle visit / Free evening (tips on where to go and where to eat will be provided) |
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| Chair: Christoph Müller | |
| 8:30–9:00 | Slavica Jonic: Hybrid methods for analyzing conformational variability in cryo-EM and cryo-ET data |
| 9:00–9:30 | Katja Petzold: What do microRNAs and ribosomes have in common? Dynamics! |
| 9:30–10:00 | Francesca Rossi: Impact of osteosarcoma cells differentiation on biomineralization and mitochondrial morphology |
| 10:00–10:30 | Johannes Thoma: In-situ characterization of the bacterial outer membrane protein A |
| 10:30–11:00 | Coffee break |
| Chair: Jiri Novacek | |
| 11:00–11:30 | Marina Mapelli: Structural and functional characterisation of mechanisms controlling epithelial tissue integrity |
| 11:30–12:00 | Lukas Trantirek: Characterizing biomolecular structure and interactions in living human cells synchronized in defined physiological states using NMR spectroscopy |
| 12:00–12:30 | Rolf Boelens: Lac Repressor allostery |
| 12:30–13:00 | Outlook and Concluding remarks iNEXT AUM (Anastassis Perrakis; NKI, Coordinator) |
| 13:00–13:20 | Sponsor's contribution – Thermo Fisher Scientific: Advances and Frontiers in Cryo Electron Microscopy |
| 13:20–14:00 | Buffet lunch |
| 14:00–14:50 | Carlos Oscar Sorzano: Deep learning for SPA |
| 14:50–15:40 | Lukas Palatinus: 3D electron diffraction: a tool for understanding pharmaceutically and biochemically relevant small molecules |
| 15:40–16:00 | Coffee break |
| 16:00–16:50 | C. Shan Xu: Volume Electron Microscopy: from Room Temperature to Cryo |
| 16:50–17:40 | Katerina Naydenova: Structure determination by cryoEM at 100 keV |
| 18:30–22:00 | Gala dinner in the Augustinian Abbey, Mendel Square |
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| 8:30–9:20 | Bruno Klaholz: High-resolution cryo-EM analysis of ribosome and virus complexes |
| 9:20–10:10 | Jurgen Plitzko: Serial-lift-out - The path to the molecular anatomy of whole organisms by cryo-electron tomography |
| 10:10–10:40 | Coffee break |
| 10:40–11:30 | Simone Mattei: Ribosomes hibernate on mitochondria during cellular stress |
| 11:30–12:20 | Holger Stark: How to improve resolution and quality in single particle cryoEM |
| 12:20–12:50 | Sponsor's contribution – TESCAN GROUP: Accelerating Cryo-TEM Sample Preparation with TESCAN plasma FIB-SEM |
| 13:00–14:00 | Buffet lunch |
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The accompanying programme can be downloaded here.
This event has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 871037, project iNEXT-Discovery. This website reflects only the author’s view and the European Commission is not responsible for any use that may be made of the information it contains.
